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Pharmacology

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Question:

What are other pathways used to oxidize lipophilic molecules other than CYP?

Author: H K



Answer:

Alcohol dehydrogenase (ADH) is an enzyme found in microsomes that oxidize alcohols in aldehydes, which is the basis of intoxication due to ethanol consuption. RK: Ethanol has a higher affinity on ADH than methanol so it can be used as a treatment of methanol toxicity. Ethanol is converted into acetaldehyde by MEOS (microsomal ethanol oxidizing system), which is then further oxidized by ALDH (aldehyde dehydrogenase) into acetate in mitochondria which is eliminated in the circulation.


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H K
H K