What are advantages and disadvantages to mass spectrometry?

Advantages: high sensitivity and able to recognize small molecules, high selectivity, fast analysis, provides quantitative results, widely applicable (used to detect proteins, lipids, nucleic acids etc.), can be used for the identification of unknown molecules. disadvantages: expensive equipment, skilled personnel needed, sample preparation can be extensive and challenging (embedding and fixation may introduce artifacts), large proteins are difficult to analyse, ionization process can be destructive to sample.