Pharmacology: What is gluthation (GSH) conjugation?

Question

What is gluthation (GSH) conjugation?

H K · Accepted Answer

GSTs (GSH transferase) multigene family found in cytosol of hepatocytes. (it is addition of glutamic acid+   cysteine + glycine).
It occurs for xenobiotics that are electrophilic.
Ex: mercapturic acids (excreted either via bile or urine)

Pharmacology

What is gluthation (GSH) conjugation?

GSTs (GSH transferase) multigene family found in cytosol of hepatocytes. (it is addition of glutamic acid+ cysteine + glycine). It occurs for xenobiotics that are electrophilic. Ex: mercapturic acids (excreted either via bile or urine)

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