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Pharmacology

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Question:

How are glucuronides excreted?

Author: H K



Answer:

Usually via urine and kidney or via active transport by hepatocytes into bile and excretion into duodenum. Many of them reenter circulation by enterohepatic circulation (reabsorbed back into the liver) beta-glucuronidase also targets them to liberate the free drug into GI lumen, where it can be transported by passive diffusion in large intestine into circulation.


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H K
H K