What is paraffin embedding and what are the pros and cons of it?

Paraffin embedding is done after the tissue is fixed (in formalin) and permeabilized. pros: better preservation of tissue architecture, long-term storage, easily obtainable for research, compatible with IHC, cost-effective, sections are physically stable. cons: preparation time takes about 2 days, shows a lot of autofluorescence, degradation of DNA and RNA, long processing time.