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GastroEnterology

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Question:

How does the liver metabolize alcohol?

Author: H K



Answer:

Liver is principal alcohol metabolising organ, as ethanol is rapidly absorbed by the upper GI, it diffuses to liver via portal vein, then alcohol dehydrogenase degrades it converting it into acetaldehyde (affecting protein synthesis) damaging hepatocytes (excess free radicals) this excess leads to inability to prevent and repair damage + kupfer cell activated leading to hepatocellular death -->fibrosis.


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Author

H K
H K