What is the treatment of UIP?

Lack of effective therapy, high-dose corticosteroids (0,5-1 mg/kg) with immunosupression Panther IPF study showed harm in prednisolone + azathioprime (compared to a placebo mortailty increased with them) NAC antioxidant (attenuates fibrosis in animals, no difference in FVC, rate, death or exacerbation noted) Pirfenidone (reduces collagen synthesis, attenuates fibrosis - 45% redcuction of FVC and improved survival) Nintedanib (thyrosine kinase inhibitor (VEGF and PDGF, reduced decline of FVC compared to placebo) Lung transplant : best option, FVC<60%, DLCO<40%, oxygen depedency, 5 year survival 50%