How does mechanical ventilation cause ARDS?

It can injure the lungs (only give 4-6 ml/kg - if we give more we may induce ARDS) It is a result of high inflation pressure (barotrauma)/ overdistention of alveoli (volutrauma)/ cyclic open and closing of alveoli (atelectotrauma) + disruption of alveolar endothelia integrity , releasing cytokines (biotrauma)