How is pathogenesis of bronchiectasis?

2 factors, insulting agent and impaired drainage, airway obstruction or defect in host defense Host response of neutrophils secreting proteases, inflammatory cytokines and ROS, create transmural inflammation, mucosal edema, cratering, ulceration and neovascularization of airways Progressive destruction is due to unopposed NE activity, neutrophils have increased viability, reduced phagocytosis, increased release of myeloperoxidase, and impaired bacterial killing (pseudomonas for example) Presence of Atopy as well converys worse clinical course in COPD and asthma CF can contribute to it through dysfunction of airway sodium and chloride channels Vitamin D deficiency as well increases colonization, inflammation and symptoms