How is pathophysiology of inhalation injuries?

Airways only, or systemic toxicity. Location and severity depends on ignition source, size and diameter of particles entering, duration of exposure and solubility of the gases inhaled. Direct damage by low molecular weight constituents of smoke due to their pH, free radical formation and reach (to alveoli and distal airways) We have 3 classes of injuries based on where they injure: upper airway, tracheobronchial, and lung parenchyma.