Question:
How is pathogenesis of PSC?
Author: H KAnswer:
Unknown cause, factors propsed: immune and genetics (CD4+ T cells, HLA DRBI - 0301 (DR3) and DRw52a alleles 149-150-151) Non-immune (Chronic portal bacteremia caused by IBD leads to chronic biliary tract infection, inflammation, portal fibrosis, and ultimately PSC.
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Author
H K