How is pathophysiology of insulin resistance?

Increased free fatty acid, lead to increase glucose production in liver and decreased glucose uptake (glycogen), leads to increased insulin secretion, less insulin sensitivity (muscle), increased Na+ reabsorption causing HTN. Another path is increased proinflammatory cytokines by adipose leading to increased FFA and same mechanism above. Dangers caused by insulin resistance include hyperinsulinemia, IGT, Dyslipidemia, HTN, coagulopathy.