Question:
What are monogenic forms of DM?
Author: H KAnswer:
Cause beta cell dysfunction (neonatal DM and MODY) small fraction of pt w/ DM (<5%), under 6 months of age, 80-85% of cases monogenic cause. Most common cause is maturity-onset diabetes of the young (MODY), which is hyperglycemia onset in early age (<25 years), characterized by impaired insulin secretionw/ minimal or no defects in insulin action, auto dominant in 13 genes.
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H K