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Endocrinology

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Question:

Describe Chylomicron formation and metabolism cycle?

Author: H K



Answer:

Intestinal mucosal cells secrete nascent TG rich chylomicrons produced from dietary lipids, then ApoCII and ApoE are transferred from HDL to chylomicron, then LPL which is activated by ApoCII degrades TGs of chylomicrons, to release fatty acids to adipose and glycerol to liver. ApoCII goes back to HDL, and we get remnant chylomicron again with ApoE and B48 only, then it binds to liver by ApoE and lose it to become chylomicron remnant again.


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H K
H K