Question:
How is the morphology of granulomatous inflammation?
Author: H KAnswer:
Epithelioid cells have pink granular cytoplasm, lymphocytes surround epithelioid cells, older granulomas have rim of fibroblasts and CT, frequently seen multinucleated giant cells (40-50 microm diameter), if certain infectious organism (Tb) see central area of necrosis (caseatous necrosis, amorphous structure, eosinophilic debris) Granuloma of Crohn disease, sarcoidosis and foreign body are non-caseating. Healing is accompanied w/fibrosis that may be extensive
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