What is macrocytic anemia?

Large erythroblasts (megaloblast), multilobed nuetrophils, due to deficiency of vitamin B12 or folate Pernicious anemia (autoimmune Ab against gastric parietal cells and intrinsic factor prevent B12 absorption in terminal ileum, neuropathy can occur lead to numbness and if severe blindness or dementia, tx vitamin B12 PRL) Folate deficiency (when we have excess need for folate like pregnancy/hemolytic anemia, give folic acid tablets