Anapath: How is evasion of apoptosis in cancer?

Question

How is evasion of apoptosis in cancer?

H K · Accepted Answer

Loss of p53 function (TP53/ overexpression of MDM2), overexpression of anti-apoptotic members (BCL2).
So we can use inhibitos of MDM2 and BCL2 as therapy

Anapath

How is evasion of apoptosis in cancer?

Loss of p53 function (TP53/ overexpression of MDM2), overexpression of anti-apoptotic members (BCL2). So we can use inhibitos of MDM2 and BCL2 as therapy

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