(A. TOXICANT-INDUCED CELLULAR DYSREGULATION) 1) Dysregulation of Transcription 1 Transcription of genetic information from DNA to mRNA is controlled largely by interplay between __ and __ 2 Hormones and vitamins, influence gene expression by binding to and activating __ 3 Xenobiotics may mimic the natural ligands, both may cause toxicity when administered at extreme doses or at critical periods during __