TOXICOLOGY: (Sustained Rise of Intracellular Ca2+)

1 Toxicants induce elevation of cytoplasmic Ca2+ levels by __

2 causes Ca2+ to move down its concentration gradient from extracellular fluid to the cytoplasm.

3 Toxicants also may increase cytosolic
Ca2+ inducing its __ from the
mitochondria or the endoplasmic
reticulum.

Question

(Sustained Rise of Intracellular Ca2+)

1 Toxicants induce elevation of cytoplasmic Ca2+ levels by  __

2 causes Ca2+ to move down its concentration gradient from extracellular fluid to the cytoplasm.

3 Toxicants also may increase cytosolic
Ca2+ inducing its __ from the
mitochondria or the endoplasmic
reticulum.

LEIGHTON DWIGHT OBILLOS · Accepted Answer

1) promoting Ca2+ influx & 
inhibiting Ca2+ efflux from the cytoplasm. (let Ca2+ enter but not let it leave)

2 Opening of the ligand or voltagegated Ca2+ channels or damage to the plasma membrane

3 leakage

1) promoting Ca2+ influx & inhibiting Ca2+ efflux from the cytoplasm. (let Ca2+ enter but not let it leave) 2 Opening of the ligand or voltagegated Ca2+ channels or damage to the plasma membrane 3 leakage