How is metals environmental pollutants (lead)?

Lead (interferes w/Ca metabolism leads to hemato, skeletal, neuro, GI and renal toxicity, exposure by air, food, and water, ingested lead harmful for children absorb more than 50% of lead from food whereas adults only 15%. In children BBB is more permeable and more suseptible to damage, so in children we see central effects and in adults we see peripheral demyelinating neuropathy. 80% bind in teeth and bone instead of Ca and remain for 20-30 years, 5-10% stay in blood and go to soft tissues. Seen by lead lines radiodense, they inhibit healing of fractures, cause damage to proximal tubules, and cause microcytic hypochromic anemia (early sign of lead accumulation due to inhibition of heme synthesis in marrow erythroid progenitors)