How is evolution of thrombosis?

1- resolution w/restoration of vascular permeability (spontaneous or therapeutic fibrinolysis for small and recent thrombus) 2-Organization (most common, starts in 48 hours), fibrous in nature, thrombus covered and penetrated by endothelia, and cells from vascular wall to which it adheres, and gradually it is replaced by CT containing collagen, neocapillaries and macrophages. If obliterating thrombus new vessels lead to permeabilization of vascular lumen (mostly incomplete/rudimentary), if no permeabilization thrombus calcifies (Rare) and form varicose vein) 3-Local extension of thrombus (vessel occlusion) 4-Distant migration as embolism 5-Bacterial suppuration of thrombus (rare)