How is neostigmine as anti-acetylcholinesterase?

Quaternary amine enters CNS poorly long acting. Synthetic compound carbamic acid ester, enhances gastric contraction and increases secretion of gastric acid, stimulates motor activity of small intestine and colon. Treats detursor atony of urinary bladder in case of urinary retention. Antidote of tubocurarine (Ach antagonist) and other competitive neuromuscular blocking agents. Symptomatic treatment of Myasthenia gravis