TOXICOLOGY: Toxic Epidermal Necrolysis

1 Manifestations:

2 Characteristic Features:

3 Drugs that contribute:

4 Mediators (they induce TEN)

Question

Toxic Epidermal Necrolysis

1 Manifestations:

2 Characteristic Features:

3 Drugs that contribute:

4 Mediators (they induce TEN)

LEIGHTON DWIGHT OBILLOS · Accepted Answer

1 - Burning skin
- Big blisters
- Death from infections (sepsis)

2 - Apoptosis (cell death) of epidermal keratinocytes

3 - Anticonvulsants
- Nonsteroidal anti-inflammatories (NSAID)
- Antibacterial - Sulfonamides- Allopurinol 
- Nevirapine

4 - Tumor necrosis factor (TNF) 
- FAS ligands

Toxic Epidermal Necrolysis 1 Manifestations: 2 Characteristic Features: 3 Drugs that contribute: 4 Mediators (they induce TEN)