How is SLE lymphadenopathy and splenomegaly clinical manifestation?

•Lymphadenopathy occurs in about 40% of patients • usually at the onset of disease or during disease flares (Shapira et al, 1996). • more likely to have constitutional symptoms •A lymph node biopsy may be warranted when the degree of lymphadenopathy is out of proportion to the activity of the lupus •Splenomegaly occurs in 10–45% of patients, particularly during active disease