Question:
How is immune activation/inflammation in SSc?
Author: H KAnswer:
Inflammation, innate, humoral and cellular immunity alteartion play a role in pathogenesis of SSc. Humoral (ANA>90%, Anti-Scl-70 [anti topoisomerase 30-40%], ACA [anticentromere, 80-90%], anti RNA pol II and III [rapid progression and internal organ involvement], antifibrillarin, anti-PM-Scl)
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Author
H K