What are characteristics of non-catecholamine adrenergic agonists?

Lack catechol hydroxyl group, longer half-life not inactivated by COMT, phenylephrine, ephedrine and amphetamine. Phenylephrine analogue of epi, ephedrine has methyl substitute. They are poor substrates for MAO, prolonged duration of action, increased lipid solubility greater CNS penetration