How is thrombosis and healing in progression of atheroma?

Repetitive cycles of plaque disruption, thrombosis in situ, and healing probably contribute to lesion evolution and plaque growth. These constitute one type of crisis in the history of a plaque may cause burst of SMC proliferation, migration and matrix synthesis. Determinants of plaque (fluid phase: tissue factor microparticles, plasma, PAI-1, fibrinogen. Solid state: thrombomodulin, macrophages, tissue factors)