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Cardiology

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Question:

How is thrombosis and healing in progression of atheroma?

Author: H K



Answer:

Repetitive cycles of plaque disruption, thrombosis in situ, and healing probably contribute to lesion evolution and plaque growth. These constitute one type of crisis in the history of a plaque may cause burst of SMC proliferation, migration and matrix synthesis. Determinants of plaque (fluid phase: tissue factor microparticles, plasma, PAI-1, fibrinogen. Solid state: thrombomodulin, macrophages, tissue factors)


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Author

H K
H K