What are SNDIs?

A2 antagonists (miratazapine (serotonin 1a agonist, others antagonist, main side effect weight gain and sedation)) SNDI action (LC [cut in brakes blocks presynaptic neurons NE increase release of NE, block presynaptic serotonin increase its release (by decreasing action)] Raphe [step on accelerator [increase NE release stimulating a1 Rs in post synaptic dendritic neurons of serotonin provoking serotonin release])