What are labs of AIHA?

• Complete blood count with red blood cell indices (eg, MCV, MCH, MCHC), reticulocyte percentage, and examination of the peripheral blood smear • Tests for hemolysis, including indirect bilirubin, lactate dehydrogenase, and haptoglobin • Direct antiglobulin (Coombs) testing, including testing for both IgG and C3 on the red cell surface • Testing for specificity of the antibody for antigens identified on red blood cells • Anemia may be severe,↑MCHC (spherocytosis), ↑MCV (reticulocyte) • ↑indirect bilirubin, ↑lactate dehydrogenase, and ↓haptoglobin. • The peripheral blood smear; spherocytes, polychromatophilic (retic) • DAT, direct antiglobulin test (Coombs); 97- 99 % of pt will exhibit apositive result with anti-IgG, anti-C3, or both (on the surface of RBC).