What is Hodgkin's lymphoma?

In contrast w/NHL, typically presents in a single node or several adjacent lymph nodes, confined to lymph nodes, seldom w/extranodal component, spreads in a contiguous fashion (one node to adjacent), consists of few neoplastic cells (Reed-Sternberg RS cells) surrounded by many benign reactive cells Little knowledge about etiology, some show evidence of EBV infection (RS cells) and cytogenetic abnormalities, surrounding inflammatory stroma results from expression of cytokines [IL and TNF] from RS cells.