What is plasma cell myeloma?

Bone marrow plasma cell infiltration (chronic pain, pathologic features, and hypercalcemia) Increased Ig production and amyloid deposition Impaired immunity (recurrent infections) Clinically (seen in pt >50 yrs old, incidence increased w/age, prognosis not very good range from 3-6 years depending on cytogenetics) Variants (smoldering, indolent, osteosclerotic, non secretory (rare, negative for M protein in urine and serum, has all other characteristics of multiple myeloma) Solitary lesion is monoclonal neoplastic plasma cells, top sites bone marrow [intramedullary], extramedullary [URT]. Bone plasmacytomas progress to plasma cell myeloma w/in 10-20 years, extraosseous plasmacytomas rarely progress and can be surgically cured.