What is transfusion related acute lung injury (TRALI)

Transfusion-Related Acute Lung Injury (TRALI) typically presents within 6 hours of a transfusion, although it can manifest up to 24 hours post-transfusion Symptoms of TRALI include acute respiratory distress, hypoxemia, fever, and hypotension. TRALI is caused by an immune reaction involving donor antibodies directed against recipient leukocytes, leading to endothelial damage and increased pulmonary vascular permeability. The recommended treatment for TRALI is supportive care, including oxygen therapy, mechanical ventilation, and hemodynamic support as needed