What is thrombophilia workup?

Workup involves a systematic approach to identify underlying causes of hypercoagulability. Here's an elaboration on the workup process. Hx (detailed, risk factors [thrombotic events, fam hx, meds, underlying medical conditions]) PE (venous and arterial thrombosis signs, inflammation of limb) Labs (basic coagulation studies (aPTT, PT, TT), specific thrombophilia tests (protein C, protein S, antithrombin III, factor V leiden mutation, prothrombin gene mutation, APP antibodies), CBC, D-dimer (elevated - non specific)) Imaging (venous US (DVT), CT angio (visualization of arterial thrombosis), MRV (pelvis and abdomen thrombosis) Special considerations (additional monitoring in pregnant women, vary based on age as well) Genetic counseling (to understand themselves and fam)