What is std therapy of cGVHD?

Prednisone 1 mg/kg/day Prolonged course, usually tapered over one year One half have resolution of GVHD Median duration of treatment is 2 years for responding patients Salvage tx (MMF, FK506, Thalidomide, Plaquenil, Pentostatin, Methotrexate, Rituximab, PUVA Extracorporeal photopheresis, Newer approaches, Low dose-IL-2, Mesenchymal Stem Cells ,Ruxolitinib (Jack inhibitors), Ibrutinib for cGVHD (breakthrough))