What are stimulants (cocaine and amphetamine)?

Increase monoamines: - dopamine (D1 and D2): reinforcing effects - norepinephrine: toxic effects - serotonin: modulates reward potency, behavioral manifestations, cocaine-seeking behavior Cocaine: Inhibits the normal reuptake of monoamines from the synaptic cleft Amphetamines: release of monoamines from storage sites in axon terminals.