How are pharmacokinetics of different ACE inhibitors?

Cleared by kidney mostly so we need dose reduction in case of impaired renal function, majority are administered as prodrugs with enhanced bioavailability compared to their active drugs Only Captopril and Lisinopril are not prodrugs, t1/2 least for captopril, most for lisinopril and fosinopril, all by kidney and only fosinopril partially by liver. Captopril was first agent to be developed so it is prototype, enalapril is prodrug most ACEIs are activated by esterification.