Question:
What is the mechanism by which ACEI can reduce GF in hypoperfusion?
Author: H KAnswer:
Ang II causes efferent arteriolar and afferent vasoconstriction, increasing pressure across glomerulus. Glomerular filtration (GFR) is maintained. Thus, during ACE inhibition, efferent arteriolar resistance decreases and glomerular filtration declines.
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