Question:
How is mechanism of action of Ca channel blockers?
Author: H KAnswer:
CCB prevent the entry of Ca to myocytes (smooth muscles mainly) through the L type Ca channels by binding on the a1 site, this leads to less actin-myosin interaction thus relaxation of different types of smooth muscles causing vasodilation, in addition to blocking of myocardial contractility, decreased HR and decreased velocity of conduction w/in heart (negative ionotropy, chronotropy, and dromotropy)
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