Question:
How is mechanism of action of digitalis?
Author: H KAnswer:
Inhibit Na+/K+ ATPase so Na+ movement is reduced, so Ca cannot be excreted outside increasing intracellularly, this change should be controlled and minimal, as it increases the resting potential may be affected and reduced (from -90 to -70) and thus make membrane more excitable increasing risk of arrhythmias (toxicity)
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H K