Question:
What is mechanism of action of class IB agents?
Author: H KAnswer:
Lidocaine, little effect on rate of depolarization, decrease duration of action potential by shortening repolarization (Phase 3 action) Rapidly dissociate Na+ channels, manifests when cardiac ell is firing rapidly, useful in treating ventricular tachy prevents re-entry of abnormal electrical impulses by shortening AP.
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H K