Pharmacology: How are pharmacokinetics of vitamin K antagonists?

Question

How are pharmacokinetics of vitamin K antagonists?

H K · Accepted Answer

Warfarin rapidly absorbed PO, 99% bound to albumin prevents diffusion to CSF, urine and breast milk but can be displaced by other drugs and lead to elevated activity.
Readily crosses placenta, half life 40 hours, metabolism by CYP450 conjugated and excreted in urine and stool

Pharmacology

How are pharmacokinetics of vitamin K antagonists?

Warfarin rapidly absorbed PO, 99% bound to albumin prevents diffusion to CSF, urine and breast milk but can be displaced by other drugs and lead to elevated activity. Readily crosses placenta, half life 40 hours, metabolism by CYP450 conjugated and excreted in urine and stool

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