How is pharmacokinetics, adverse effects and drug interactions for bile acid sequestrants?

Pharmacokinetic Cholestyramine is taken orally. Because it is a very large (high molecular weight), it is neither absorbed nor metabolically altered by the intestine. It is totally excreted by the feces. Adverse Effects Gastrointestinal disturbances such as constipation, nausea and flatulence. Drug-Drug Interactions Cholestyramine bind and decrease the absorption of many drugs, including: Some Thiazides, Digoxin, Warfarin, some statins (Pravastatin and Fluvastatin) NB: these drugs should be taken at least 1 to 2 hours before, or 4 to 6 hours after