Question:
What are COMT-I?
Author: H KAnswer:
Tolcapone (acts peripherally and centrally, fatal hepatic failure) Entacapone (acts peripherally) COMT inhibited, L DOPA becomes 3-O methyldopa instead of DA which competes w/levodopa in active transport to CNS) Staleva (levodopa, carbidopa, entacapone)
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Author
H K