What is familial renal cell carcinoma?

1/von Hippel-Lindau +++: RCC develops in about 50% of patients with vonHippel-Lindau disease and is distinctive for its early age at onset (often in the third, fourth, or fifth decade of life) and for its bilateral and multifocal involvement due to a mutation in VHL tumor suppressor gene 2/Hereditary papillary RCC 3/Familial Leiomyomatosis and RCC