How does alcohol cause chronic pancreatitis?

70% of Pt Dose and Duration related Varied in each individual Onset : At age 35-40 yr Or at 16-20 yr of alc. consumption Mechanism not clear SAPE theory Pancreatic Stellate cell (PSC) activation Multiple-Hit Theory Necrosis-Fibrosis sequence Alcohol Interfere transport of Digestive enz.  Colocalization  Acinar cell inj. Depletion of Lithostathine  inc. Pancreatic stone formation