What are risk factors of exocrine tumors?

Risk Factor Family History : 2-3 times risk Cigarette smoking : at least 2 times Coffee &alcohol : ?? Other GI malignancy Hi-fat , Low-fiber / Fruits / vegetables Pre-existing type II DM Chronic Familial Pancreatitis : 20 times Oncogenesis : Likely initiated with Mutation of K-ras oncogene