How is systemic tx of PsO?

• Phototherapy UVB-311nm NB: Targeted UVB therapy can be effective for “diffuse areas of psoriasis”. 2-3 sessions per week • Methotrexate: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis. The dose in psoriasis is 15-25 mg/week with regular screening CBC, LFT’s • Cyclosporine: an immunosuppressive drug C62H111N11O12 that is a cyclic polypeptide obtained as a metabolite from a fungus (Tolypocladium inflatum) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis. Contraindicated in HTN • Apremilast: anti-PDE4. Inhibition of PDE4 results in ↑ intracellular levels of cyclic adenosine monophosphate (cAMP). Indicated in PsO and PsA