What are risk factors of drug reactions?

• Female • Prior history of drug reaction • Recurrent drug exposure: repeated courses of drug therapy with the same drugs are associated with higher rates of adverse drug reactions • HLA-B type: 1502 (carbamazepine and SJS/TEN) 5701 (abacavir and Dress), 5801 (allopurinol and SJS/TEN) • Reactions to aminopenicillin in EBV infection • HIV+ patients have high rate of dermatologic skin reactions to drug as to sulfones and other drugs