Question:
How is morphology of giant cell arteritis?
Author: H KAnswer:
Gross: Involved segment of the artery show nodular thickening of the intima → reduces the size of lumen → ischemia. Microscopy • Granulomatous inflammation (within the inner tunica media centered on the internal elastic lamina. It shows multinucleated giant cells) • Fragmentation of elastic lamina. • Chronic inflammation (consisting of T cells and macrophages.) • Segmental distribution of inflammation with segments of relatively normal artery between the lesions. • Intimal fibrosis in healed stage.
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H K![H K](https://lh4.googleusercontent.com/-V3rEIOcuFis/AAAAAAAAAAI/AAAAAAAAAAA/AMZuucnhTzvoiq2vqvBJhe7t9kqRkO_jNw/s96-c/photo.jpg)