How is splenectomy in dx?

• Diagnostic workup integrating clinical and imaging data, and data from PB and BM investigations, can help recognizing most cases of lymphomas presenting as unexplained splenomegaly as specific B- or T-cell lymphoma histotypes. • However, in a minority of cases: – generic diagnosis of B-cell chronic lymphoproliferative disorder, – or it can even leave the nature of the splenomegaly unsolved